Official quality control method for the first-generation bisphosphonate clodronate, which inhibits bone resorption and is used to treat bone weakness or pain caused by cancer that has spread to the skeleton. This analysis was performed according to the European Pharmacopoeia monograph method which is used to determine related substances that could be present as impurities […]
Year: 2020
Quantification of common anions in bottled drinking water according to EPA method 300.1A
Official procedure for quality control of drinking water according to the United States Environmental Protection Agency. This procedure allows quantification of the seven common inorganic anions fluoride, chloride, nitrite, bromide, nitrate, phosphate and sulfate in the ranges recommended by WHO and national authorities. This application was set up on a flexible modular HPLC system, equipped […]
Modernized assay for foscarnet following ICH guidelines
New assay for the antiviral medication forscarnet which is a DNA polymerase inhibitor that is used to combat herpes viruses, including drug-resistant cytomegalovirus, and to treat patients with HIV as part of salvage therapy. This assay was developed by Diduco to meet the requirements in the ICH guidelines, as a contribution to the United States […]
Determination of sulfamate and sulfate in topiramate tables according to USP monograph
Official quality control method for the second-generation antiepileptic drug topiramate which also have shown effect against migranes. This analysis was performed according to the United States Pharmacopeia monograph and determines the degradation products sulfamate and sulfate which can be formed during storage in humid environments or at elevated temperatures. Without suppressor, the p-hydroxybenzoic acid eluent […]
Analysis of dietary supplement capsules with carnitine using a generic method for counterions
Oral L-carnitine is a dietary supplement that has been shown to reduce fatigue in elderly people with low muscular endurance, but its effects on athletes during physical activity are not well-supported. Although this endogenous compound is well-known for its involvement in the mitochondrial oxidation of long-chain fatty acids, no scientific evidence has been found that […]
Screening of contaminants and forced degradation products in lithium ion battery electrolyte
Electrolytes in rechargeable batteries for cars, mobile phones, and other portable electric devices typically contain negatively charged counterions that together with lithium and a non-aqueous solvent form an ionic liquid. The bis(fluorosulfonyl)imide anion is a rather new ionic liquid constituent which thus need new quality control procedures. This application uses a straightforward carbonate eluent to […]